Tumor Cells and Micro-environment in Brain Metastases
10.3779/j.issn.1009-3419.2016.09.12
- VernacularTitle:脑转移肿瘤细胞及其微环境
- Author:
ZHONG WEN
1
;
HU CHENGPING
Author Information
1. 中南大学湘雅医院呼吸内科
- Keywords:
Brain metastases;
Tumor microenvironment;
Astrocyte;
Microglia;
Blood brain barrier;
Angiogenesis
- From:
Chinese Journal of Lung Cancer
2016;19(9):626-635
- CountryChina
- Language:Chinese
-
Abstract:
Improvements in survival and quality of life of patients with lung cancer had been achieved due to the progression of early diagnosis and precision medicine at recent years, however, until now, treatments targeted at lesions in cen-tral nervous system are far from satisfying, thus threatening livelihood of patients involved. Atfer all, in the issue of prophylaxis and therapeutics of brain metastases, it is crucial to learn about the biological behavior of tumor cells in brain metastases and its mechanism underlying, and the hypothesis ”seed and soil”, that is, tumor cells would generate series of adaptive changes to ift in the new environment, is liable to help explain this process well. In this assay, we reviewed documents concerning tumor cells, brain micro-environments and their interactions in brain metastases, aiming to provide novel insight into the treatments of brain metastases.
