The Role of SOCS in the Development of Tumors
10.3779/j.issn.1009-3419.2016.09.11
- VernacularTitle:SOCS家族分子在肿瘤发生发展中的作用
- Author:
LIU CHUNLAI
1
;
LIU HONGYU
;
CHEN JUN
Author Information
1. 天津医科大学总医院肺部肿瘤外科
- Keywords:
Suppressor of cytokine signaling (SOCS);
JAK-STAT;
Methylation
- From:
Chinese Journal of Lung Cancer
2016;19(9):620-625
- CountryChina
- Language:Chinese
-
Abstract:
Suppressor of cytokine signaling (SOCS) family proteins are a group of negative regulatory factors that plays important roles in the negative regulation of cytokine responses by terminating the activation of the JAK-STAT and other signaling pathways. hTe family is composed of eight structurally related proteins. mainly through the inhibition of the activation of JAK-STAT signaling pathway and regulates cell proliferation, differentiation and apoptosis. In the process of tumor progres-sion, the promoter CG island hypermethylation, gene mutation, gene deletion and inactivation lead to the abnormal expres-sion of SOCS protein make JAK-STAT continuous activation, resulting in the development and metastasis of tumor. Here, we review the SOCS family members found, composition and molecular structure, the domain of the function, and the latest progress of development in tumor. Based on the important role of SOCS in tumor development, SOCS as a negative regulator factor represent a kind of tumor suppressor genes, has become a new target for tumor therapy.
