Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor
10.3779/j.issn.1009-3419.2016.09.10
- VernacularTitle:血管紧张素II及其受体与恶性肿瘤关系的研究进展
- Author:
SUN LULU
1
;
SHI JIAN
Author Information
1. 河北医科大学
- Keywords:
Tumor;
Angiotensin II;
Angiotensin II 1 receptor;
Angiotensin II 2 receptor
- From:
Chinese Journal of Lung Cancer
2016;19(9):615-619
- CountryChina
- Language:Chinese
-
Abstract:
Angiotensin AngII, a linear small peptide,which is composed of eight amino acids, is the main effectors of renin-angiotensin systen (Renin-angiotensin system, ARS). AngII, a main biopolypeptide of the ARS, has important patho-physiologic in effects participating in cardiac hypertrophy, vascular cell proproliferation, inlfammation and tissue remodeling through G-protein-coupled receptors. In recent years, Ang II can promote tumor cell proliferation, tumor vessel formation and inhibit the differentiation of the tumor cells. hTis suggests that inhibit the production of AngII or block its effect is expected to become a new measure for the treatment of malignant tumors. hTis article reviews the advances in research on the relationship between AngII and its receptor and malignant tumor in recent years.
