Additional Subconjunctival Low Dose 5-fluoro u racil Injection after Mitomycin C Applied Filtering Surgery in Glaucoma Patients.
- Author:
Seon Hoo KIM
1
;
Hyun Joon PARK
Author Information
1. Department of Ophthalmology, Gachon Medical School, Gil Medical Center.
- Publication Type:Original Article
- Keywords:
Trabeculectomy;
Triple surgery;
MMC;
5-FU
- MeSH:
Filtering Surgery*;
Fluorouracil;
Glaucoma*;
Humans;
Intraocular Pressure;
Mitomycin*;
Postoperative Complications;
Trabeculectomy
- From:Journal of the Korean Ophthalmological Society
2000;41(1):197-204
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To evaluate the additive efficacy of postoperative low dose 5-FU subconjunctival injection, we analyzed 43 patients[43 eyes]who had undergone trabeculectomy or triple surgery with intraoperative MMC for 2.5~3min.18eyes[case group =MMC 5-FU group]of 43 eyes had postoperative low dose 5-FU injection additionally and 25 eyes[control group =MMC group]of which had only undergone intraoperative MMC. The mean[+/-SD]follow-up periods were 13.6 +/-5.3 months in MMC 5-FU group and 12.1 +/-3.6 months in MMC group.There was no statistically significant difference in preoperative IOP between the two groups[p>0.05].Mean postoperative intraocular pressures were 12.9 +/-4.2 mms of mercury in MMC 5-FU group and 13.3 +/-4.4 mms of mercury in MMC group at 12 months postoperatively[p>0.05]. Kaplan-Meier survival analysis showed that the cumulative success rates at 1.5 year were 82.6%and 87.2%in the case and control groups, respectively[p>0.05].Of the postoperative complications, corneal epithelial defect was more frequent in MMC 5-FU group[p<0.05]. In conclusion, postoperative injection of low dose 5-FU additionally did not have an additive effect on the IOP control in patients undergone MMC applied filtering surgery. We may need additional postoperative injection of higher dose of 5-FU.Or, we may need to individualize the duration of application or the concentration of intraoperative MMC to begin with.
