Clinical features and treatment outcome of extranodal nasal-type NK/T-cell lymphoma of the extra-upper aerodigestive tract
10.3760/cma.j.cn112152-20191207-00789
- VernacularTitle:上呼吸消化道外结外鼻型NK/T细胞淋巴瘤临床特征和预后
- Author:
Yuting ZHAO
1
;
Ying WANG
;
Shunan QI
;
Yong YANG
;
Xia HE
;
Yujing ZHANG
;
Huiqiang HUANG
;
Liling ZHANG
;
Gang WU
;
Baolin QU
;
Liting QIAN
;
Xiaorong HOU
;
Fuquan ZHANG
;
Xueying QIAO
;
Hua WANG
;
Gaofeng LI
;
Yuan ZHU
;
Jianzhong CAO
;
Junxin WU
;
Tao WU
;
Suyu ZHU
;
Mei SHI
;
Liming XU
;
Zhiyong YUAN
;
Hang SU
;
Yuqin SONG
;
Jun ZHU
;
Yexiong LI
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院放疗科 100021
- Keywords:
Lymphoma, NK/T-cell;
Radiotherapy;
Chemotherapy;
Prognosis
- From:
Chinese Journal of Oncology
2021;43(7):787-794
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features and prognosis of extranodal nasal-type NK/T-cell lymphoma of the extra-upper aerodigestive tract (extra-UADT NKTCL).Methods:The clinical data of 159 patients with extra-UADT NKTCL from the China Lymphoma Collaborative Group (CLCG) database between November 2001 and December 2015 were retrospectively analyzed. Kaplan-Meier survival analysis and Log-rank test were used to evaluate the prognosis. The Cox regression model is used for multi-factor analysis.Results:Extra-UADT NKTCL commonly occurs in skin and soft tissues (106/159, 66.7%) and gastrointestinal tract (31/159, 19.5%). The incidences of elevated lactate dehydrogenase (LDH) and Ann Arbor Ⅲ~Ⅳ stage were 47.8% (76/159) and 64.2% (102/159), respectively. The 3-year overall survival (OS) and progression-free survival (PFS) rates were 43.6% and 27.9%, respectively. The corresponding OS rates of primary skin/soft tissue site and gastrointestinal tract site were 41.0% and 59.4% ( P=0.281), while the PFS rates were 24.8% and 48.3%, respectively ( P=0.109). Combined modality treatment improved the 3-year OS of all the patients (58.4% vs 33.9%, P=0.001) and 3-year PFS (40.7% vs 20.7%, P=0.008) when compared with chemotherapy alone. LDH elevation, Ann Arbor synthesising and ≥2 junction external bits were intrusive as independent risk factors for total survival ( P<0.05), LDH elevation and ≥2 junction outer bits were intrusive as independent risk factors for progressionless survival( P<0.05). The distant extranodal dissemination was the primary failure patterns. Conclusions:Extra-UADT NKTCL appears to have distinct clinical characteristics and poor outcome. Compared with chemotherapy alone, combined modality treatment may improve the prognosis of patients with extra-UADT NKTCL.
