Clinical Features of Intradural Extramedullary Spinal Cord Metastases in Primary Lung Cancer
10.3779/j.issn.1009-3419.2016.08.10
- VernacularTitle:肺癌硬膜下脊髓外转移患者临床特征分析
- Author:
XU YAN
1
;
ZHONG WEI
;
ZHAO JING
;
CHEN MINJIANG
;
LI LONGYUN
;
WANG MENGZHAO
Author Information
1. 100730北京，中国医学科学院，北京协和医学院，北京协和医院呼吸内科
- Keywords:
Lung neoplasms;
Leptomeningeal metastasis;
Spinal cord;
Intradural extramedullary metastases
- From:
Chinese Journal of Lung Cancer
2016;19(8):539-544
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Intradural extramedullary spinal cord metastases in lung cancer is rare, and it leads to severe neurological damage. hTe aim of this study is to identify the clinical features of intradural extramedullary spinal cord metastases in primary lung cancer patients.Methods hTe 8 cases of lung cancer with intradural extramedullary metastases, who were hospitalized in Peking Union Medical College Hospital (PUMCH) during May 2013 to May 2016, were enrolled in the retrospective study. Medical charts of the 8 patients were reviewed systematically.Results Intradural extramed-ullary spinal cord metastases was diagnosed in 7 cases with non-small cell lung cancer (NSCLC) and 1 case with small cell lung cancer (SCLC). Cauda equina syndrome was the most common clinical manifestation. Malignant cells in cerebrospinal lfuid were positive in all the 5 cases (100%) who underwent lumbar puncture. Contrast-enhanced magnetic resonance imaging (MRI) of spine manifested as diffuse abnormal enhancement of pial lining of spinal cordin 3 cases, intradural extramedullary nodules in 4 cases, and both of them in 1 case. Neurological symptoms were improved or stable in 4 cases who underwent targeted therapy and/or radiotherapy. hTe median overall survival was 5.8 months.Conclusion Intradural extramedullary spinal cord metastases can be diagnosed with caution according to its neurological symptoms and contrast-enhanced MRI presentation. Targeted therapy and/or radiotherapy may be effective for symptoms control.
