Analysis of the efficacy and prognostic factors of 1 637 esophageal cancer patients treated with intensity-modulated radiotherapy
10.3760/cma.j.cn112152-20201031-00952
- VernacularTitle:1 637例食管癌调强放射治疗的疗效和预后因素分析
- Author:
Chen LI
1
;
Lijun TAN
;
Xiao LIU
;
Weiming HAN
;
Linrui GAO
;
Shijia WANG
;
Zongmei ZHOU
;
Qinfu FENG
;
Dongfu CHEN
;
Jun LIANG
;
Jima LYU
;
Wenqing WANG
;
Zhouguang HUI
;
Lyuhua WANG
;
Xin WANG
;
Wenyang LIU
;
Lei DENG
;
Jianyang WANG
;
Yirui ZHAI
;
Tao ZHANG
;
Nan BI
;
Zefen XIAO
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院放疗科 100021
- Keywords:
Esophageal neoplasms;
Radiotherapy, intensity-modulated;
Treatment modality;
Prognosis
- From:
Chinese Journal of Oncology
2021;43(6):678-684
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize survival outcomes and prognostic factors in esophageal cancer (EC) patients treated with intensity-modulated radiotherapy (IMRT).Methods:A retrospective analysis was performed on the clinical and follow-up data of 1 637 patients with EC who were admitted to our hospital from January 2005 to December 2017 and met the inclusion criteria.The 5-year overall survival (OS), progression-free survival (PFS) and pattern of recurrence were analyzed. The Kaplan-Meier method was used to calculate survival rates, Log-rank test for univariate analysis and Cox method for multivariate analysis were used to detect survival difference.Results:1-year, 3-year and 5-year OS and PFS of the entire group were 65.9% and 45.8%, 34.2% and 25.0%, 27.0% and 18.5%, respectively. Median OS and PFS were 19.4 months (95% CI=18.0-20.7 months) and 10.4 months (95% CI=9.3-11.3 months), respectively. Univariate analysis showed that the sex, KPS, tumor location, T stage, N stage, M stage, TNM stage, radiation dose and treatment modality were prognostic factors for 5-year OS and PFS of EC patients ( P<0.05). Multivariate analysis indicated that the sex, KPS, TNM stage, radiation dose and treatment modality were independent prognostic factors for 5-year OS and PFS ( P<0.05). Conclusions:EC patients treated with IMRT can obtain a promising survival. The sex, KPS, TNM stage, radiation dose and treatment modality are independent prognostic factors for prognosis.
