Thymectomy versus Tumor Resection for Early-stage Thymic Malignancies：A Chi-nese Alliance for Research in Thymomas (ChART) Retrospective Database Analysis
10.3779/j.issn.1009-3419.2016.07.08
- VernacularTitle:胸腺切除范围对早期胸腺上皮肿瘤预后的影响
- Author:
GU ZHITAO
1
;
FU JIANHUA
;
SHEN YI
;
WEI YUCHENG
;
TAN LIJIE
;
ZHANG PENG
;
HAN YONGTAO
;
CHEN CHUN
;
ZHANG RENQUAN
;
LI YIN
;
CHEN KE-NENG
;
CHEN HEZHONG
;
LIU YONGYU
;
CUI YOUBING
;
WANG YUN
;
PANG LIEWEN
;
YU ZHENTAO
;
ZHOU XINMING
;
LIU YANGCHUN
;
LIU YUAN
;
FANG WENTAO
Author Information
1. 上海交通大学附属上海胸科医院
- Keywords:
Thymic epithelial tumors;
Myasthenia gravis;
hTymectomy;
hTymomectomy
- From:
Chinese Journal of Lung Cancer
2016;19(7):459-464
- CountryChina
- Language:Chinese
-
Abstract:
Background and objectiveTo evaluate the surgical outcomes of tumor resection with or without total thymectomy for thymic epithelial tumors (TETs) using the Chinese Alliance for Research in Thymomas (ChART) retrospec-tive database.Methods Patients without preoperative therapy, who underwent surgery for early-stage (Masaoka-Koga stage I and II) tumors, were enrolled for the study. They were divided into thymectomy and thymomectomy groups according to the resection extent of the thymus. Demographic and surgical outcomes were compared between the two patients groups. Results A total of 1,047 patients were enrolled, with 796 cases in the thymectomy group and 251 cases in the thymomec-tomy group. Improvement rate of myasthenia gravis (MG) was higher atfer thymectomy than atfer thymomectomy (91.6%vs 50.0%,P<0.001). Ten-year overall survival was similar between the two groups (90.9% atfer thymectomy and 89.4% atfer thymomectomy,P=0.732). Overall, recurrence rate was 3.1% atfer thymectomy and 5.4% atfer thymomectomy, with no sig-niifcant difference between the two groups (P=0.149). Stratiifed analysis revealed no signiifcant difference in recurrence rates in Masaoka-Koga stage I tumors (3.2%vs 1.4%,P=0.259). However in patients with Masaoka-Koga stage II tumors, recurrence was signiifcantly less atfer thymectomy group than atfer thymomectomy (2.9%vs 14.5%,P=0.001).Conclusion hTymectomy, instead of tumor resection alone, should still be recommended as the surgical standard for thymic malignancies, especially for stage II tumors and those with concomitant MG.
