Application of BRAF in the diagnosis and treatment of thyroid papillary carcinoma

VernacularTitle:鼠类肉瘤滤过性毒菌致癌同源体B1基因在甲状腺乳头状癌诊断和治疗中的应用
Author: Ting ZOU ¹ ; Yun PAN ; Lixia WANG
Author Information

1. 大理大学临床医学院　671000
Keywords: Thyroid papillary carcinoma; Murine sarcoma viral oncogene homolog B1; Diagnosis; Treatment
From: Chinese Journal of Oncology 2021;43(6):629-634
CountryChina
Language:Chinese
Abstract: Thyroid cancer is the most common endocrine malignancy, and thyroid carcinoma (PTC) has the highest incidence rate, accounts for about 85%~90% of thyroid carcinoma. There are many markers of PTC, such as murine sarcoma viral oncogene homolog B1 (BRAF), telomerase reverse transcriptase, Ki-67, microRNA-146b, PDZ and LIM domain 5 (PDLIM5). Among them, BRAF plays an important role in the carcinogenesis, development and prognosis of PTC. This article summarizes the research progress of BRAF signaling pathway, its role in the carcinogenesis, development and prognosis of PTC, its clinical correlation with the clinical pathological characteristics of PTC, and its application in the diagnosis and treatment of PTC to provide the references to readers.