Surgery treatment and prognosis analysis of 129 small cell carcinoma of the esophagogastric junction
10.3760/cma.j.cn112152-20200713-00652
- VernacularTitle:129例食管胃结合部小细胞癌的外科治疗及预后分析
- Author:
Baozhong LI
1
;
Ming HE
;
Xin CHEN
;
Hui ZHU
;
Xinjian XU
Author Information
1. 首都医科大学附属北京世纪坛医院胸部外科 100038
- Keywords:
Esophagogastric junction neoplasms;
Small cell cancer;
Surgery;
Prognosis;
Survival analysis
- From:
Chinese Journal of Oncology
2021;43(4):490-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analysis the prognosis related factors of patients with small cell cancer of the esophagogastric junction treated by surgery.Methods:The clinicopathologic data of 129 patients with small cell cancer of the esophagogastric junction underwent surgery treatment in the Fourth Hospital of Hebei Medical University from January 2004 to December 2010 were retrospectively analyzed. Univariate survival survival was performed by Kaplan-Meier method and Log rank test. Multivariate survival was analyzed by using Cox proportional hazard model.Results:Radical surgery was performed in 123 patients, whereas other 6 cases were conducted palliative operation. The 5-year overall survival (OS) rate of this cohort was 21.0% and median survival time was 25.7 months. The 5-year progression free survival (PFS) rate of this cohort was 11.0% and median PFS time was 19.1 months. The univariate analysis result showed that operation manner, radical or not, tumor length, lymph node metastasis, TNM stage, intravascular cancer embolus surgical margin positive or not, the expression of Syn, comprehensive treatment and radiochemotherapy after progression were associated with the OS of these patients ( P<0.05). Multivariate analysis result showed that lymph node metastasis, radiochemotherapy after progression were independent risk factors of OS ( P<0.05). Univariate analysis result showed that operation manner, radical or not, tumor length, TNM stage, lymph node metastasis, intravascular cancer embolus, surgical margin positive or not, the expression of Syn, comprehensive treatment and radiochemotherapy after progression were associated with PFS ( P<0.05). Multivariate analysis showed that lymph node metastasis and radiochemotherapy after progression were independent risk factors of PFS ( P<0.05). Conclusions:The prognosis of small cell cancer of the esophagogastric junction patients remains poor. Lymph node metastasis and radiochemotherapy after progression are regarded as independent prognostic factors of these patients.
