Evaluation of Pulmonary Hypertension with CMR：Pulmonary Hypertension Patients and Healthy Volunteers Control Study
10.3779/j.issn.1009-3419.2016.05.07
- VernacularTitle:CMR评估肺高血压：肺高血压患者与健康志愿者对照研究
- Author:
WANG MENG
1
;
YANG ZHENWEN
;
ZHANG ZHANG
;
LI DONG
;
YANG FAN
;
YU TIELIAN
Author Information
1. 天津医科大学总医院放射科
- Keywords:
Cardiac;
Magnetic resonance;
Pulmonary hypertension;
Right ventricle;
Pulmonary artery
- From:
Chinese Journal of Lung Cancer
2016;19(5):293-298
- CountryChina
- Language:Chinese
-
Abstract:
Background and objectivehTe clinical course of pulmonary hypertension (PH) is one of progressive deterioration interspersed with episodes of acute decompensation. It is diffcult to predict when patients will die because death may come either suddenly or slowly due to progressive heart failure. hTe aim of this study is to investigate morphology, func-tion and hemodynamics in PH, compared with healthy people, and to investigate the clinical value of detection of PH by use of cardiac magnetic resonance (CMR) parameters.MethodsCMR was performed in 56 PH patients collected from Tianjin Medical University General Hospital from January 2012 to December 2014 and 22 healthy controls. hTe following parameters were calculated: right ventricle (RV) end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), myocar-dial mass (MM), RV fractional area change (RVFAC), interventricular septal curvature (CIVS), letf ventricular free wall curva-ture (CFW), and CIVS/CFW, main pulmonary artery (MPA) positive peak velocity, maximal area, minimal area and distensibility. Comparisons of CMR measurements between PH patients and controls were analyzed by using the studentt-tests. Receiver operating characteristic (ROC) curve analysis was used to compare the PH diagnostic abilities for four parameters (MPA posi-tive peak velocity, distensibility, curvature ratio, and RVFAC) and combined CMR parameter.P<0.05 was considered signiif-cant.Results Compared with healthy controls, RV morphology, function and hemodynamics of PH group declined and dete-riorate obviously. hTe ROC curve analysis showed that among the four parameters distensibility of MPA had the highest AUC value (AUC=0.95). Additionally, combined CMR parameter (positive peak velocity+distensibility+curvature ratio+RVFAC) had even higher AUC (AUC=0.988).ConclusionComprehensive CMR parameters is conducive to accurately relfect the overall state RV-pulmonary circulation in patients with PH.
