CT Guided Radiofrequency Ablation Followed Intratumoral Chemotherapy in the Treatment of Early Stage Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2016.05.04
- VernacularTitle:CT引导射频消融与瘤内化疗治疗早期非小细胞肺癌的临床研究
- Author:
FENG WEIJIAN
1
;
LI JIN
;
HAN SUHONG
;
TANG JINFENG
;
YAO JIE
;
CUI YUQING
;
WANG CHUNTANG
;
CHEN ZHONGCHENG
;
LI XIAOGUANG
;
ZHI XIUYI
Author Information
1. 100038北京，首都医科大学附属复兴医院，首都医科大学肿瘤学系
- Keywords:
Lung neoplasms;
Radiofrequency ablation;
Intratumor chemotherapy
- From:
Chinese Journal of Lung Cancer
2016;19(5):269-278
- CountryChina
- Language:Chinese
-
Abstract:
Background and objectiveRadiofrequency ablation (RFA) has become one of the local treatment for inoperable early stage non-small cell lung cancer (NSCLC). hTis study observes effectiveness and safety of computed tomog-raphy (CT) guided RFA followed intratumoral chemotherapy (RFA-ITC).MethodsFrom 2005 to 2015, our group perspec-tively enrolled inoperable early stage NSCLC underwent RFA-ITC duo to poor cardiopulmonary function or with other dis-eases or patient can't tolerate or reject surgery. RFA was performed by a directive apparatus assisted CT guided semi real-time and step-by-step puncture method, conformal umbrella-shaped electrode and single or multiple targets ablation. While the plan ifnished and CT showed normal lung tissue around the tumor present ground-glass opacity (GGO), the procedure ended, then 200 mg of carboplatinum were injected into the tumor via the electrode needle. Safety and effectiveness were evaluated byfollow-up.Results Technical success rates of 125 RFA-ITC treatments of 110 patients were 100%. hTe median survival was 48.0 months, overall survival (OS) was 55.4 months, progression-free survival was 55.1 months, 1, 2, 3, 5-year OS rates were 100%, 90.7%, 62.7%, 21.9%, respectively. Survival of GGO presence or not was 68.3 months and 40.1 months, respectively (P=0.001). hTe survival rates of the N1 staging and tumor size was no signiifcant difference. No perioperative deaths occurred, the main complicationsi.e. pneumothorax, pulmonary hemorrhage, pleural effusion, fever, intraoperative chest pain, subcuta-neous emphysema, intraoperative cough were slight and tolerable.ConclusionCT guided RFA-ITC provides a good method for treatment of inoperable early stage NSCLC with better survival, less complication and small damage.
