Current Research of the Roles of IL-35 in Tumor Progression
10.3779/j.issn.1009-3419.2016.04.09
- VernacularTitle:白细胞介素35的在肿瘤发展中的作用
- Author:
HUANG CHONGBIAO
1
;
TIAN YE
;
CUI YAN
;
XU JIE
;
XIN LIANG
;
YANG XUELING
;
QI DALIANG
Author Information
1. 300060天津，国家癌症临床研究中心，天津市肿瘤防治重点实验室，天津医科大学肿瘤医院高级病房
- Keywords:
Interleukin;
Interleukin-35;
Tumor;
Tumor immunology
- From:
Chinese Journal of Lung Cancer
2016;19(4):230-235
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the ifeld of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of anαchain P35 and aβchain Epstein-Barr virus induced gene 3 (EBI3). Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inlfammatory diseases and autoim-mune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression.
