Differential brain angiotensin-II type I receptor expression in hypertensive rats.
10.4142/jvs.2011.12.3.291
- Author:
Valdir A BRAGA
1
Author Information
1. Veterinary Sciences Department, Center for Agrarian Sciences, Federal University of Paraiba, Areia, PB 58397-000, Brazil. valdir@cca.ufpb.br
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
blood pressure;
losartan;
rostral ventrolateral medulla;
subfornical organ;
sympathetic activity
- MeSH:
Angiotensin II/*metabolism;
Animals;
Hypertension/chemically induced/*metabolism;
Male;
Medulla Oblongata/*metabolism;
RNA, Messenger/genetics;
Rats;
Rats, Wistar;
Receptor, Angiotensin, Type 1/*genetics;
Reverse Transcriptase Polymerase Chain Reaction;
Signal Transduction;
Subfornical Organ/*metabolism
- From:Journal of Veterinary Science
2011;12(3):291-293
- CountryRepublic of Korea
- Language:English
-
Abstract:
Blood-borne angiotensin-II (Ang-II) has profound effects in the brain. We tested the hypothesis that Ang-II-dependent hypertension involves differential Ang-II type I (AT1) receptors expression in the subfornical organ (SFO) and the rostral ventrolateral medulla (RVLM). Male Wistar rats were implanted with 14-day osmotic minipump filled with Ang-II (150 ng/kg/min) or saline. AT1 receptor mRNA levels were detected in the SFO and RVLM by reverse transcription-polymerase chain reaction (RT-PCR). Ang-II caused hypertension (134 +/- 10 mmHg vs. 98 +/- 9 mmHg, n = 9, p < 0.05). RT-PCR revealed that Ang-II infusion induced increased AT1 receptor mRNA levels in RVLM and decreased in SFO. Our data suggest that Ang-II-induced hypertension involves differential expression of brain AT1 receptors.
