Advances in Research of Osteopontion and Its Receptor CD44v in Tumor Invasion and Metastasis
10.3779/j.issn.1009-3419.2015.11.11
- VernacularTitle:骨桥蛋白及其受体CD44v对肿瘤侵袭调控的研究进展
- Author:
SUN BINGSHENG
1
;
ZHANG ZHENFA
Author Information
1. 300060天津，天津医科大学肿瘤医院肺部肿瘤科，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市肺癌诊治中心
- Keywords:
Osteopontion;
CD44v;
Signaling pathways;
Tumor progression
- From:
Chinese Journal of Lung Cancer
2015;(11):714-717
- CountryChina
- Language:Chinese
-
Abstract:
Osteopontin (OPN) is a multifunctional, extracellular matrix-associated, secretory, glyco-protein. It can be used as an adhesion protein involved in tumor cell adhesion,migration; but also as a cytokine, promoting tumor angiogen-esis, evading immune surveillance and inhibiting cellular apoptosis. CD44v glycoprotein, is one of the cell surface adhesion molecule that mediates cell-matrix and cell-cell interactions. Extensive research has suggested the important role of OPN in regulating signaling pathways that contribute to tumor progression and metastasis, and the serum level is associated with the prognosis of various malignancies. hTerefore, clarifying OPN in the molecular mechanisms of tumor progression and its signal-ing pathway contributes to seeking a novel anti-cancer therapy.
