Correlation of serum neuregulin 4 level with sex hormone and metabolism level in patients with polycysticovary syndrome
- VernacularTitle:多囊卵巢综合征患者血清神经调节蛋白4水平与性激素及代谢水平的相关性分析
- Author:
Yang SHAO
1
;
Chao YAO
;
Songyuan XU
;
Ping QIANG
Author Information
- Keywords: neuregulin 4; polycystic ovary syndrome; glucolipid metabolism; sex hormone
- From: Journal of Clinical Medicine in Practice 2024;28(10):112-115
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the correlations of serum neuregulin 4(NRG4)level with sex hormone and metabolism level in patients with polycystic ovary syndrome(PCOS).Methods A total of 87 PCOS patients were selected as the study subjects(PCOS group),and 90 healthy women(no reproductive system diseases,normal menstruation and normal sex hormone examination)were selected as the control group.Enzyme-linked immunosorbent assay(ELISA)was used to detect ser-um NRG4 level,glucose and lipid metabolism indexes and sex hormone indexes.Pearson method and multiple linear regression were used to analyze the correlation between serum NRG4 and various inde-xes in PCOS patients.Results The serum NRG4 level in PCOS group was(24.41±7.31)ng/mL,which was significantly higher than(15.43±4.26)ng/mL in the control group(P＜0.001).Com-pared with the control group,the levels of BMI,hypersensitive C-reactive protein(hs-CRP),fasting blood glucose(FBG),fasting insulin(FINS),insulin resistance index(HOMA-IR),triglyceride(TG),luteinizing hormone(LH),luteinizing hormone/follicle stimulating hormone(LH/FSH),prolactin and total testosterone in PCOS group were significantly increased(P＜0.05).Serum NRG4 levels in PCOS patients were positively correlated with BMI,hs-CRP,FBG,FINS,HOMA-IR,TG,LH,LH/FSH and total testosterone(P＜0.05);the BMI,FBG and TG were the influencing factors of serum NRG4 level(P＜0.05).Conclusion The increase of serum NRG4 level in PCOS patients is associated with abnormal glucose and lipid metabolism and sex hormone indexes.
