Predictive value of combined testing for immunoglobulin binding protein 1 in serum and urine in lupus nephritis
- VernacularTitle:血清和尿液联合检测免疫球蛋白结合蛋白1在狼疮性肾炎中的预测价值
- Author:
Caiyue BIAN
1
;
Yilu QIN
;
Shu LIANG
;
Xiao GAO
;
Jie WU
;
Wenqiang FAN
Author Information
- Keywords: immunoglobulin binding protein 1; serum; urine; systemic lupus erythematosus; lupus nephritis; combined detection
- From: Journal of Clinical Medicine in Practice 2024;28(10):83-86,95
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the predictive value of combined detection of immunoglobulin binding protein 1(IGBP 1)in serum and urine in lupus nephritis(LN).Methods A total of 60 LN patients were selected as LN group,and 60 SLE erythematosus(SLE)patients in the same period were selected as SLE group,the serum IGBP 1 and urinary IGBP 1 levels between the two groups were compared,and the value of serum IGBP 1,urinary IGBP 1 and their combination in predicting LN was analyzed.Results Serum IGBP 1 and urinary IGBP 1 in the LN group were significantly higher than those in the SLE group(P＜0.05).Binary Logistic regression analysis showed that serum IGBP 1 and urinary IGBP 1 were risk factors for LN(P＜0.05).Receiver Operating Characteristic(ROC)curve revealed that the area under the curve(AUC)for serum IGBP1,urinary IGBP1,and their combined detection for LN was 0.856,0.834,and 0.902,respectively.The Youden index was 0.533,0.533,and 0.666,respectively.The sensitivity and specificity of serum IGBP1 were 85.0％and 68.3％,re-spectively.The sensitivity and specificity of urinary IGBP1 were 53.3％and 100.0％,respectively.The sensitivity and specificity of the combined detection were 78.3％and 88.3％,respectively.Con-clusion Serum IGBP 1 and urinary IGBP 1 are highly expressed in LN patients,and their combina-tion has a high predictive value for LN.
