Advances in Diagnosis and Treatment of Multiple Primary Lung Cancer
10.3779/j.issn.1009-3419.2015.10.07
- VernacularTitle:多原发性肺癌的诊治进展
- Author:
LUO WENXIN
1
;
ZHOU PING
;
LI WEIMIN
Author Information
1. 四川大学华西医院呼吸科
- Keywords:
Lung neoplasms;
Molecular markers;
Mutations;
Surgery;
Stereotactic ablative radiotherapy
- From:
Chinese Journal of Lung Cancer
2015;(10):640-643
- CountryChina
- Language:Chinese
-
Abstract:
Recently, the incidence and detection rates of multiple primary lung cancer (MPLC) are increasing. hTe diagnosis of MPLC depends mainly on the Martini-Melamed criterion and ACCP criterion at present, taking all features (histological, genetic, radiologic and clinical) into account. It may be easy to diagnose cases of MPLC that exhibit different his-tological types, but it is diffcult to diagnose cases that exhibit similar histological type. DNA polity, gene mutations, microsatel-lite alteration and so on provide new methods for the accurate diagnosis of MPLC. hTey can evaluate the clonal relationship and help differential diagnosis between MPLC and metastasis. hTe ifrst therapeutic choice for MPLC is curative operation. hTe surgical approach includes lobectomy, wedge resection and segmentectomy. For those which cannot be resected, we can synthesize chemotherapy, radiotherapy, stereotactic ablative radiotherapy (SABR), radiofrequency ablation (RFA), molecular targeted therapy, etc.
