Mechanism of Platinum Derivatives Induced Kidney Injury
10.3779/j.issn.1009-3419.2015.09.09
- VernacularTitle:铂类抗肿瘤药物相关肾损伤作用机制的研究进展
- Author:
YAN FEIFEI
1
;
DUAN JIANCHUN
;
WANG JIE
Author Information
1. 北京大学肿瘤医院 北京大学临床肿瘤学院 胸部肿瘤内一科
- Keywords:
Platinum derivatives;
Kidney injury;
Mechanism
- From:
Chinese Journal of Lung Cancer
2015;(9):580-586
- CountryChina
- Language:Chinese
-
Abstract:
Platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors, lung cancer, and colorectal cancer. Two major problems exist, however, in the clinic use of platinum derivatives. One is the development of tumor resistance to the drug during therapy, leading to treatment failure. hTe other is the drug’s toxicity such as the cisplatin’s nephrotoxicity, which limits the dose that can be admin-istered. hTis paper describes the mechanism of platinum derivatives induced kidney injury.
