Relationship between Expression of TGF-β1, Smad2, Smad4 and Prognosis of Patients with Resected Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2015.09.03
- VernacularTitle:TGF-β1、Smad2和Smad4蛋白表达在可手术切除非小细胞肺癌中的表达
- Author:
XIE MIAN
1
;
HE CHAOSHENG
;
WEI SHENHAI
Author Information
1. 510120 广州，广州医科大学附属第一医院呼吸疾病国家重点实验室，广东省人民医院内科
- Keywords:
Transforming growth factorβ;
Smad;
Lung neoplasms
- From:
Chinese Journal of Lung Cancer
2015;(9):543-548
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective It has been proven that any changes of transforming growth factorβ(TGF-β)-Smad signal transduction pathway will lead to abnormalities of signal transmission and the out of control during cell growth and differentiation, resulting in cancer development. hTe aim of this study is to investigate the prognostic values of TGF-β1, Smad2 and Smad4 in resected non-small cell lung cancer (NSCLC). Methods hTe expression of TGF-β1, Smad2, and Smad4 was evaluated by immunohistochemistry in 85 patients with NSCLC. hTe relationships among the expression of these proteins, clinicopathological factors, and prognosis were also analyzed. Results TGF-β1 positive expression was signiif-cantly correlated with the late stage and lymph node involvement. No signiifcant association existed between the expression of Smad2 and the clinicopathological characteristics. hTe lack of Smad4 expression was associated with the advanced tumor stage (P=0.014). Multivariate analysis indicated that lymph node involvement (P=0.001) was an independent prognostic factor in the 85 NSCLC patients. hTe positive expression levels of TGF-β1 (P=0.032) and N stage (P=0.028) were demonstrated to be independent risk factors for survival among 47 lung adenocarcinoma patients. Adenocarcinoma patients with TGF-β1 positive expression demonstrated an unfavorable survival outcome (P=0.0376). Conclusion TGF-β1 may be an independent predic-tor of survival in resected lung adenocarcinoma patients.
