Regional distribution and clinicopathological characteristics of Epstein-Barr virus associated gastric cancer
10.3760/cma.j.cn112152-20200305-00171
- VernacularTitle:EB病毒相关胃癌地域分布特点及临床病理特征分析
- Author:
Chunfang HU
1
;
Hua LIN
;
Yanjia CHEN
;
Hongtian DAI
;
Bingzhi WANG
;
Liyan XUE
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院病理科 100021
- Keywords:
Gastric adenocarcinoma;
Epstein-Barr virus;
In situ hybridization;
Regional distribution;
Clinicopathological feature
- From:
Chinese Journal of Oncology
2020;42(11):943-948
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate regional distribution and clinicopathological features of Epstein-Barr virus associated gastric cancer (EBVaGC).Methods:Epstein-Barr virus encoded RNA (EBER)was detected in 4 081 cases of gastric adenocarcinoma in Cancer Hospital, Chinese Academy of Medical Sciences by using in situ hybridization. EBVaGCs were identified and their proportions in different provinces, autonomous regions and municipalities were compared. The correlation between EBVaGC and clinicopathological features was also analyzed.Results:A total of 3.0% (123/4 081) patients with gastric adenocarcinoma are EBVaGCs. Among the areas with cases more than 90, the highest proportion of EBVaGC was found in Jilin province, accounting for 7.6%, and then followed by 5.4% in Liaoning province, 4.1% in Anhui province, 3.9% in Beijing, 3.7% in Inner Mongolia Autonomous Region, 3.4% in Shanxi province, 3.0% in Heilongjiang province, 2.1% in Shandong province, 1.6% in Hebei province, and no EBVaGC was found in Henan province. EBVaGC proportions are significantly different in these provinces, autonomous regions and municipalities ( P<0.05). Multivariate analysis of logistic regression revealed that gender ( OR=2.231, 95% CI: 1.290~3.858), WHO classification ( OR=2.338, 95% CI: 2.051~2.664) and N stage ( OR=0.420, 95% CI: 0.284~0.621) were independent impact factors for EBVaGC. The proportion of EBVaGC was higher in males, gastric carcinomas accompanied with lymphoid stroma and patients without lymph node metastasis. Conclusions:The proportion of EBVaGC in gastric adenocarcinoma displays area distribution disparity in China. The gender, WHO classification and N stage are closely associated with EBVaGC.
