Retrospectively Analysis of Factors Inlfuencing the Relapse (or Progression) of Newly Diagnosed Nonoperative Small Cell Lung Cancer
10.3779/j.issn.1009-3419.2015.09.01
- VernacularTitle:初治非手术小细胞肺癌复发/进展影响因素的回顾性分析
- Author:
ZHUANG YAQIN
1
,
2
;
JIANG LIYAN
;
ZHAO YIZHUO
;
QIAN JIALIN
;
GAO XIWEN
Author Information
1. 200030上海，上海交通大学附属胸科医院肺内科
2. 201199上海，上海市闵行区中心医院呼吸内科
- Keywords:
Lung neoplasms;
Chemotherapy;
Radiotherapy;
Relapse
- From:
Chinese Journal of Lung Cancer
2015;(9):529-536
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Most small cell lung cancer (SCLC) patients relapse or progress and have low survival rate although they have signiifcant response to initial chemotherapy and radiotherapy. hTis study intends to explore the factors affecting the relapse (or progression) of nonoperative SCLC and to explore the correlations between progression-free survival (PFS) and overall survival (OS). Methods Clinical data of 182 patients diagnosed with SCLC between January 2009 and December 2011 at Shanghai Chest Hospital has been reviewed and retrospectively analyzed. All of these patients ac-cepted chemotherapy combined (or not combined) with radiotherapy, and relapsed or progressed atfer ifrst-line therapy. Uni-variate Kaplan-Meier survival estimates as well as multivariate Cox regression survival analysis were used to locate the potential factors affecting PFS. hTe correlation between PFS and OS was analyzed via Bivariate Correlation Analysis method. Results hTe univariate estimates showed that the TNM stage, liver metastasis or not, brain metastasis or not, ifrst-line chemotherapy cycles, effect of initial chemotherapy, and thoracic radiotherapy combined or not were the signiifcant contributive factors to PFS. In the subgroup of the patients without brain metastases, those received prophylactic cranial irradiation (PCI) had longer PFS. Cox regression indicated that the three independent variables of ifrst-line chemotherapy cycles, effect of initial chemo-therapy and thoracic radiotherapy combined or not were closely related to PFS. In addition, signiifcant positive correlation between PFS and OS had been observed. Conclusion PFS could be prolonged by having more ifrst-line chemotherapy cycles (>4 cycles), obtaining better effect of initial chemotherapy (partial response or complete response), combining with thoracic radiotherapy and implementing PCI for patients without brain metastasis.
