Operative efficacy of 13 malignant uterine tumors after Cf-252 intracavitary irradiation
10.3760/cma.j.cn112152-20190903-00570
- VernacularTitle:13例子宫肿瘤锎-252中子腔内放疗后的手术效果
- Author:
Ping BAI
1
;
Jie BU
;
Ren LI
;
Ping SUN
;
Hui SUN
;
Jianheng SUN
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院妇瘤科 100021
- Keywords:
Uterine neoplasms;
Endometrial neoplasms;
Cf-252 brachytherapy;
Surgery
- From:
Chinese Journal of Oncology
2020;42(10):882-884
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the surgical therapeutic efficacy of uterine tumors patients underwent Cf-252 neutron intra-cavity and external radiotherapy, and evaluate the application value of Cf-252 neutron radiotherapy.Methods:Thirteen cases of uterine tumor with local suspicious lesions or poor prognostic factors after CF-252 neutron intracavity and external radiotherapy were treated with surgery. Among them, 12 cases underwent extrafascial hysterectomy, 1 case underwent extensive hysterectomy and lymphadenectomy. The postoperative pathology and follow-up results were used to evaluate the efficacy.Results:Nine cases showed severe response to radiotherapy in postoperative cervical pathological tissues without residual tumor, and survived for more than 3-14 years, the median survival time was 8 years. All of 4 cases with residual tumor died within 1 year. Delayed healing of vaginal wounds occurred in 3 of the 12 cases.Conclusions:Cf-252 is a good brachytherapy source. The cervical tissue shows severe response to radiotherapy and prolonged healing time of vaginal wound is observed in some cases after CF-252 radiotherapy. To those uterine tumor patients with local suspicious lesions or poor prognostic factors after CF-252 neutron intracavity and external radiotherapy, extrafascial hysterectomy is a safe and feasible treatment method.
