Analysis of Survival Predictors in Patients with Lung Cancer and Brain Metastases
10.3779/j.issn.1009-3419.2015.07.08
- VernacularTitle:肺癌脑转移生存预测因素分析
- Author:
CUI SHAOHUA
1
;
BAI HAO
;
DONG LILI
;
ZHAO YIZHUO
;
GU AIQIN
;
ZHANG WEI
;
LOU YUQING
;
JIANG LIYAN
Author Information
1. 上海交通大学附属胸科医院呼吸内科
- Keywords:
Lung neoplasms;
Brain metastases;
Predictor;
Survival
- From:
Chinese Journal of Lung Cancer
2015;(7):436-442
- CountryChina
- Language:Chinese
-
Abstract:
Background and objectivehTe prognosis for patients with lung cancer and brain metastases remains poor, with approximately 6 months of survival, despite active measures atfer treatment. In this study, we determined and ana-lyzed clinical parameters that affect the survival of patients with lung cancer and brain metastases to provide clinical guidance. MethodsLung cancer cases with brain metastases were retrospectively collected during 2002 and 2008 from Shanghai Chest Hospital, Shanghai Jiao Tong University.Kaplan-Meier method andCox regression were performed for univariate and multi-variate analyses, respectively, to explore independent predictors inlfuencing the survival of patients with lung cancer and brain metastases.Results Age, Eastern Cooperative Oncology Group performance status (ECOG PS), metastasis interval, number of metastasis, treatment method, treatment period, symptoms of brain metastases, extracranial metastasis, and brain metastasis order were factors that affect the survival of patients with brain metastases as conifrmed through theKaplan-Meiermethod. Treatment periods and extracranial metastasis were independent survival predictors in patients with lung cancer and brain me-tastasis as indicated byCox proportional hazard model.ConclusionTreatment periods and extracranial metastasis were inde-pendent predictors of survival of patients with lung cancer and brain metastasis. Treatment periods and extracranial metastasis were independent predictors of survival of patients with lung cancer and brain metastasis.
