Three-dimensional Mass Measurement of Subsolid Pulmonary Nodules on Chest CT:Intra and Inter-observer Variability
10.3779/j.issn.1009-3419.2015.05.06
- VernacularTitle:亚实性肺结节CT三维质量分析：观察者内及观察者间差异
- Author:
LIU HUITING
1
;
WANG YING
;
FENG LEI
;
YU TIELIAN
Author Information
1. 天津医科大学总医院放射科
- Keywords:
Subsolid nodules;
Mass measurement;
Volume measurement;
Computed tomography;
Repeatability This study was supported by the grants from the National Natural Science Foundation of China (to Ying
- From:
Chinese Journal of Lung Cancer
2015;(5):289-294
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Subsolid pulmonary nodules tend to exhibit considerably slower growth rates than solid lesions, nevertheless, higher malignancy probability. hTe diagnosis of indeterminate nodules largely depends on the growth evaluation during follow-up. hTe growth can manifested as an increase in size or the appearance and/or subsequent increase of solid components. hTe mass relfect the product of volume and density and can be more sensitive in growth evalu-ation. However, the repeatability needs a further validation. hTe purpose of this study is to assess the intra and inter-observer variability of mass measurement for subsolid nodules. Methods 80 subsolid nodules in 44 patients were retrospectively en-rolled. Both the volume and mass were measured by two radiologists using blind method independently. Intra-observer and inter-observer variability were analyzed and compared by Bland-Altman method intra-class correlation test and Wilcoxon test. Results Sotfware achieved satisifed segmentation for 92.5%nodules. Of them, 35%underwent manual modiifcation. hTe 95%limits of agreement for intra-observer variability were-11.5%-10.4%for mass and-8.4%-8.8%for volume. hTe 95%limits of agreement for inter-observer variability were-17.4%-19.3%for mass and-17.9%-19.4%for volume.hTe intra-class correlation foeffcients between volume and mass measument was 0.95 and 0.93 (both P<0.001) and no signiifcant differences (P=0.78, 0.09) was found for intra-and inter-observer variability. Manual modiifcation of the segmentation caused the worse mass mea-surement repeatability in spite of the reader satisfaction. Conclusion hTe repeatability of mass measurement has no signiifcant difference with that of volume measurement and may act as a reliable method in the follow-up of subsolid nodules.
