Establishment and validation of a Nomogram prediction model for risk of multi-drug resistant infection after operation of cerebral hemorrhage
- VernacularTitle:脑出血术后多重耐药感染风险的诺模图预测模型的构建与验证
- Author:
Hui CHEN
1
;
Li ZHANG
;
Chen LU
;
Xindi CAI
Author Information
- Keywords: cerebral hemorrhage; multi-drug resistant infection; risk factors; the Glasgow Coma Scale; Nomogram
- From: Journal of Clinical Medicine in Practice 2024;28(8):45-49,54
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the risk factors for postoperative multi-drug resistant infection in patients with cerebral hemorrhage and establish a Nomogram prediction model.Methods Clinical materials of 241 patients with surgery for cerebral hemorrhage in the hospital from July 2020 to July 2023 were collected,and they were divided into infection group and non-infection group.Logistic re-gression models were used to analyze independent influencing factors for the occurrence of postopera-tive multi-drug resistant infection in patients with cerebral hemorrhage,and a Nomogram prediction model was constructed accordingly.The predictive performance of the Nomogram was evaluated by the consistency index(C-index),the receiver operating characteristic(ROC)curve,and the calibration curve.Results A total of 241 patients with cerebral hemorrhage were included in this study,among which 56 cases(24.24％)had postoperative multi-drug resistant infection.In the infection group,the preoperative Glasgow Coma Scale(GCS)score,ratio of preoperative vomiting,ratio of preopera-tive antibiotic treatment,ratio of gastric tube indwelling,ratio of tracheotomy,and ratio of intubation were significantly higher than those in the non-infection group(P＜0.05).Logistic regression analy-sis revealed that preoperative GCS score ≤ 8,preoperative vomiting,preoperative antibiotic treatment,gastric tube indwelling,tracheotomy and intubation were the independent risk factors for postoperative multi-drug resistant infection in patients with cerebral hemorrhage(OR＞1,P＜0.05).Values of ar-ea under thecurve(AUC)for preoperative GCS score,preoperative vomiting,preoperative antibiotic treatment,tracheotomy and intubation were all above 0.700,indicating these indicators have good predictive value for the occurrence of postoperative multi-drug resistant infection in such patients.Based on these influencing factors,a Nomogram risk model was established.The C-index value of the calibration curve was 0.798,suggesting the Nomogram model has good discriminatory power.The AUC values for the modeling group and validation group in the ROC curve were 0.798 and 0.722 respectively,indicating that the Nomogram model possesses satisfactory predictive efficacy.Conclusion Nomogram prediction model constructed based on independent risk factors for postop-erative multi-drug resistant infection in patients with cerebral hemorrhage can effectively predict the probability of such infections occurring in these patients after surgery.
