Acute Response of Right Ventricular Function to Iloprost Inhalations in Patients with Pulmonary Arterial Hypertension：Preliminary Evaluation with Cardiac Magnetic Resonance Imaging
10.3779/j.issn.1009-3419.2015.03.07
- VernacularTitle:吸入伊洛前列素对肺动脉高压患者右心室功能改善的即刻效应：心脏MRI初步研究
- Author:
LU QINGQING
1
;
LI DONG
;
YANG ZHENWEN
;
HAN YAN
;
CUI QIAN
;
ZHANG ZHANG
;
YU TIELIAN
Author Information
1. 天津医科大学总医院放射科
- Keywords:
Magnetic resonance imaging;
Iloprost;
Hypertension;
Pulmonary;
Ventricular function,right
- From:
Chinese Journal of Lung Cancer
2015;(3):167-171
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Pulmonary arterial hypertension (PAH) is a progressive disorder character-ized by abnormally elevated blood pressure of the pulmonary circulation. Without treatment, PAH progresses rapidly to right ventricular (RV) failure and even death. Cardiac magnetic resonance imaging (CMRI) has been an accurate and reproducible tool to assessment of RV morphology and function, which are important factors in the prognosis of patients with PAH. e aim of this study is to investigate acute RV response to inhalation of aerosolized iloprost in patients with PAH using CMRI. Method From March 2012 to March 2014, 48 patients with PAH underwent CMRI before and immediately aer inhalation of iloprost with a single dose of 20 μg over 15 min-20 min. RV function parameters derived from CMRI images were analyzed before and aer iloprost inhalation, including end-diastolic volume (EDV), end-diastolic area (EDA), end-systolic volume (ESV), end-systolic area (ESA), stroke volume (SV), ejection fraction (EF) and cardiac output (CO). Percentage of RV area change was also calculated [%RVAC=(EDA-ESA)/EDA×100%]. Wilcoxon's Sign Rank Test or Paired Samples t-Test was used to compare the dierences of RV function parameters before and aer inhalation. Results Aer iloprost inhalation, all patients showed significant decrease in RV EDV and RV ESV (P=0.007, P<0.001 respectively). Whereas, there were significant increase in RV SV (P=0.014), RV EF (P=0.009) and %RVAC (P=0.006). RV CO had no significant dierence before and aer inhalation (P=0.851). Conclusions Inhalation of iloprost can immediately improve RV function in patients with PAH, and noninvasive evaluation of the acute response with CMRI is feasibility.
