Density and SUV Ratios from PET/CT in the Detection of Mediastinal Lymph Node Metastasis in Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2015.03.05
- VernacularTitle:PET/CT密度比与摄取比判断肺癌纵隔淋巴结转移的研究
- Author:
SHAO TINGTING
1
;
YU LIJUAN
;
LI YINGCI
;
CHEN MUNAN
Author Information
1. 哈尔滨医科大学附属肿瘤医院PET/CT-MRI中心
- Keywords:
Positron emission tomography;
Computed tomography;
Density ratio;
SUV ratio;
Lung neoplasms;
Lymph node metastasis
- From:
Chinese Journal of Lung Cancer
2015;(3):155-160
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Mediastinal involvement in lung cancer is a highly significant prognostic fac-tor for survival, and accurate staging of the mediastinum will correctly identify patients who will benefit the most from surgery. Positron emission tomography/computed tomography (PET/CT) has become the standard imaging modality for the staging of patients with lung cancer. e aim of this study is to investigate 18-fluoro-2-deoxy-glucose (18F-FDG) PET/CT imaging in the detection of mediastinal disease in lung cancer. Methods A total of 72 patients newly diagnosed with non-small cell lung cancer (NSCLC) who underwent preoperative whole-body 18F-FDG PET/CT were retrospectively included. All patients underwent radical surgery and mediastinal lymph node dissection. Mediastinal disease was histologically confirmed in 45 of 413 lymph nodes. PET/CT doctors analyzed patients’ visual images and evaluated lymph node’s short axis, lymph node’s maxi-mum standardized uptake value (SUVmax), node/aorta density ratio, node/aorta SUV ratio, and other parameters using the histopathological results as the reference standard. e optimal cutovalue for each ratio was determined by receiver operator characteristic curve analysis. Results Using a threshold of 0.9 for density ratio and 1.2 for SUV ratio yielded high accuracy for the detection of mediastinal disease. e lymph node’s short axis, lymph node’s SUVmax, density ratio, and SUV ratio of integrated PET/CT for the accuracy of diagnosing mediastinal lymph node was 95.2%. e diagnostic accuracy of mediastinal lymph node with conventional PET/CT was 89.8%, whereas that of PET/CT comprehensive analysis was 90.8%. Conclusion Node/aorta density ratio and SUV ratio may be complimentary to conventional visual interpretation and SUVmax measure-ment. e use of lymph node’s short axis, lymph node’s SUVmax, and both ratios in combination is beer than either conven-tional PET/CT analysis or PET/CT comprehensive analysis in the assessment of mediastinal disease in NSCLC patients.
