Advancement of Phenotype Transformation of Cancer-associated Fibroblasts:from Genetic Alterations to Epigenetic Modiifcation
10.3779/j.issn.1009-3419.2015.02.12
- VernacularTitle:癌相关成纤维细胞表型转换的遗传学与表观遗传学机制研究现状
- Author:
CHEN DALI
1
;
CHE GUOWEI
Author Information
1. 四川大学华西医院胸外科
- Keywords:
Cancer-associated ifbroblasts;
Epigenetics;
Phenotype transformation
- From:
Chinese Journal of Lung Cancer
2015;(2):117-122
- CountryChina
- Language:Chinese
-
Abstract:
In the ifeld of human cancer research, even though the vast majority attentions were paid to tumor cells as“the seeds”, the roles of tumor microenvironments as“the soil”are gradually explored in recent years. As a dominant com-partment of tumor microenvironments, cancer-associated ifbroblasts (CAFs) were discovered to correlated with tumorigenesis, tumor progression and prognosis. And the exploration of the mechanisms of CAF phenotype transformation would conducive to the further understand of the CAFs function in human cancers. As we known that CAFs have four main origins, including epithelial cells, endothelial cells, mesenchymal stem cells (MSCs) and local mesenchymal cells. However, researchers found that all these origins ifnally conduct similiar phenotypes from intrinsic to extrinsic ones. hTus, what and how a mechanism can conduct the phenotype transformation of CAFs with different origins? Two viewpoints are proposed to try to answer the quet-sion, involving genetic alterations and epigenetic modiifcations. hTis review will systematically summarize the advancement of mechanisms of CAF phenotype transformations in the aspect of genentic and epigenetic modiifcations.
