Interaction between MicroRNAs and OCT4

VernacularTitle:MicroRNAs与OCT4基因之间的相互作用
Author: CHEN CHEN ¹ ; MENG FANRONG ; WAN HAISU ; ZHOU QINGHUA
Author Information

1. 300052 天津，天津医科大学总医院，天津市肺癌研究所，天津市肺癌转移与肿瘤微环境实验室
Keywords: MicroRNAs; OCT4; Cancer; Embryonic stem cell; Pluripotency
From: Chinese Journal of Lung Cancer 2015;(1):55-58
CountryChina
Language:Chinese
Abstract: Octamer-binding transcription factor 4 (OCT4) belongs to the POU-homeodomain family of tran-scription factors and binds to an octamer motif, ATGCAAAT. OCT4 is the key transcription factor that is involved in the maintenance of pluripotency and self-renewal in undiferentiated embryonic stem (ES) cells. OCT4 has been reported to be overexpressed in various cancers including lung, germ cell tumors, breast, cervix, prostate, gastric, liver, and ovarian cancer. Mi-croRNAs (miRNAs), small non-coding RNAs, modulate mRNA expression through base pairing between seed sequences in miRNA and complementary sequences of the target mRNA, thereby destabilizing mRNA and/or inhibiting protein synthesis. Several miRNAs have been demonstrated to regulate stemness factors such as OCT4, NANOG, SOX2 and KLF4 in cancer cells, thereby modulating the proliferation, apoptosis, diferentiation, drug resistance and immunity of cancer cells.