Relationship among Alcohol Consumption, Facial Flushing Response and Dyslipidemia in Male.
10.15384/kjhp.2016.16.3.153
- Author:
Kyu Pill KIM
1
;
Jong Sung KIM
;
Sung Soo KIM
;
Jin Kyu JUNG
;
Seok Joon YOON
;
Chang Jung WEI
Author Information
1. Department of Family Medicine, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, Korea. jskim@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
Alcohol drinking;
Flushing;
Dyslipidemias;
High density lipoprotein cholesterol;
Triglycerides
- MeSH:
Alcohol Drinking*;
Alcoholics;
Aldehyde Dehydrogenase;
Asian Continental Ancestry Group;
Cholesterol;
Cholesterol, HDL;
Cross-Sectional Studies;
Drinking;
Dyslipidemias*;
Education;
Flushing*;
Genotype;
Humans;
Hypertriglyceridemia;
Lipoproteins;
Logistic Models;
Male*;
Odds Ratio;
Triglycerides
- From:Korean Journal of Health Promotion
2016;16(3):153-161
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Facial flushing response to drinking is observed in East Asians with deficient activity of the variant aldehyde dehydrogenase 2 genotype. This study examined the role of flushing response in the relationship between alcohol consumption and dyslipidemia. METHODS: This cross-sectional study included 1,443 Korean men, including 261 non-drinkers, 470 flushers and 712 non-flushers. Based on a questionnaire, weekly alcohol consumption was assessed and categorized into 4 groups. Dyslipidemia was defined by the National Cholesterol Education Program-Adult Treatment Panel III criteria. After adjusting for confounding factors, we evaluated the relationship between weekly alcoholic drinks and dyslipidemia in flushers and non-flushers by comparing with non-drinkers, using a multi-variable logistic regression analysis. RESULTS: Non-flushers had a significant relationship between hypertriglyceridemia and alcohol consumption in two groups (4-8 drinks: adjusted odds ratio [aOR] 1.937, 95% confidence interval [CI] 1.029-3.644; ≥16 drinks: aOR 2.118, 95% CI 1.272-3.527) in contrast to flushers, who showed no significant relationship between hypertriglyceridemia and alcohol consumption. Non-flushers had a significant relationship to low serum high density lipoprotein (HDL) cholesterol levels in four groups (<4 drinks: aOR 0.428, 95% CI 0.277-0.662; 4-8 drinks: aOR 0.409, 95% CI 0.216-0.774; 8-16 drinks: aOR 0.285, 95% CI 0.152-0.536; ≥16 drinks: aOR 0.343, 95% CI 0.207-0.568), and flushers had a significant relationship in two groups (8-16 drinks: aOR 0.234, 95% CI 0.102-0.536; ≥16 drinks: aOR 0.342, 95% CI 0.166-0.705). CONCLUSIONS: Our results suggest that drinking alcohol increases the risk of hypertriglyceridemia in non-flushers and the risk of low HDL cholesterol flushers.
