Status and Advances of RGD Molecular Imaging in Lung Cancer
10.3779/j.issn.1009-3419.2014.12.06
- VernacularTitle:RGD分子影像在肺癌的研究现状与进展
- Author:
YUE NING
1
;
YUAN SHUANGHU
;
YANG GUOREN
Author Information
1. 250117 济南，山东省医学科学院，山东省肿瘤医院核医学科
- Keywords:
RGD;
Integrin;
Lung neoplasms;
Molecular imaging;
Angiogenesis
- From:
Chinese Journal of Lung Cancer
2014;(12):855-859
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer has been one of the most common and the highest mortality rates malignant tumors at home and abroad. Sustained angiogenesis was not only the characteristic of malignant tumors, but also the foundation of tumor proliferation, invasion, recurrence and metastasis, it was also one of the hot spots of treatments in lung cancer biology currently. Integrins played an important part in tumor angiogenesis. Arg-Gly-Asp (RGD) peptides could combine with integrins speciif-cally, and the application of radionuclide-labeled RGD molecular probes enabled imaging of tumor blood vessels to relfect its changes. hTe lung cancer imaging of RGD peptides at home and abroad in recent years was reviewed in this article.
