Effect and Signiifcance of BH3-only Protein in Targeted Therapy of Non-small Cell Lung Cancer

VernacularTitle:BH3-only蛋白在非小细胞肺癌靶向治疗中的作用及意义
Author: GAO WEISONG ¹ ; HUANG WENYAN ; LIU KAISHAN
Author Information

1. 暨南大学医学院病理系
Keywords: Lung neoplasms; BIM; BH3-only protein; Apoptosis; Target therapy
From: Chinese Journal of Lung Cancer 2014;(11):819-823
CountryChina
Language:Chinese
Abstract: Lung cancer is the leading cause of cancer deaths throughout the world. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti-cancer therapy, promotion of apoptosis in NSCLC is an important part of treatment, but anticancer drugs have the toxic side effects, resistance and other problems. hTerefore, the search for new targets of anticancer drugs becomes one of the foci in the treatment of NSCLC. hTe BH3-only protein plays an important role in activation and communication in apoptosis pathways. BIM is the core member in BH3-only protein family. hTe target at BIM in the treatment of NSCLC has an irreplaceable role. hTis paper brielfy describes the BCL-2 family and BH3-only pro-apoptotic protein, elaborates the important role of BIM and BH3-only protein in targeted therapy of NSCLC.