Advances in the Relationship Between Tumor Cell Metabolism and Tumor Metastasis

VernacularTitle:肿瘤细胞代谢与肿瘤转移相互关系的研究进展
Author: ZHANG YALONG ¹ ; FANG NIANZHEN ; YOU JIACONG ; ZHOU QINGHUA
Author Information

1. 300052天津，天津医科大学总医院，天津市肺癌研究所，天津市肺癌转移与肿瘤微环境重点实验
Keywords: Tumor; Metabolism of tumor cells; Tumor metastasis
From: Chinese Journal of Lung Cancer 2014;(11):812-818
CountryChina
Language:Chinese
Abstract: Intracellular nutrients and the rate of energy lfowing in tumor cells are otfen higher than that in normal cells due to the prolonged stress of tumor-speciifc microenvironment. In this context, the metabolism of tumor cells provides the fuel of bio-synthesis and energy required for tumor metastasis. Consistent with this, the abnormal metabolism such as extremely active glucose metabolism and excessive accumulating of fatty acid is also discovered in metastatic tumors. Previous Studies have conifrmed that the regulation of tumor metabolism can affect the tumor metastasis, and some of these have been successfully applied in clinical effective, positive way. hTus, targeting metabolism of tumor cells might be an effectively positive way to prevent the metastasis of tumor. So, our review is focused on the research development of the relationship between tu-mor metabolism and metastasis as well as the underlying mechanism.