Advancement of Relationship between Metabolic Alteration in Cancer-associated Fibroblasts and Tumor Progression in Lung Cancer
10.3779/j.issn.1009-3419.2014.09.07
- VernacularTitle:肺癌演进与癌相关成纤维细胞代谢转变的关系及进展
- Author:
DU HENG
1
;
CHE GUOWEI
Author Information
1. 四川大学华西医院胸外科
- Keywords:
Cancer-associated ifbroblasts;
Metabolic alteration;
Lung neoplasms
- From:
Chinese Journal of Lung Cancer
2014;(9):679-684
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microenvironment is closely related to tumor progression. Cancer-associated ifbroblasts (CAFs) are specialized ifbroblasts domesticated by cancer cells surrounding them. CAFs are one of the most important components in cancer microenvironment. CAFs extensively involved in tumor genesis, tumor invasion and metastasis. Compared to NFs, CAFs also have a different metabolism type. CAFs use glycolysis to produce lactate for cancer cells. hTat is, CAFs turn to a metabolism type named“reverse Warburg effect”to promote tumor progression. In the present study, we summarized that:(1) Characteristics and metabolic type of CAFs;(2) hTe research status of the metabolism of CAFs;(3) hTe potential mechanism of CAFs metabolism;(4) hTe relation between metabolic alteration in CAFs and lung cancer progression;(5) Relationship between CAFs metabolism and lung cancer prognosis and therapy.
