Application of Target Peptide in siRNA Delivery for the Research of Lung Cancer Therapy
10.3779/j.issn.1009-3419.2014.09.06
- VernacularTitle:靶向肽在递送siRNA进行肺癌治疗研究中的应用
- Author:
GAO HONGLIN
1
;
LIU JIANFENG
;
SONG NALING
Author Information
1. 300192 天津，中国医学科学院北京协和医学院放射医学研究所，天津市放射医学与分子核医学重点实验室
- Keywords:
Lung neoplasms;
Target peptide;
siRNA
- From:
Chinese Journal of Lung Cancer
2014;(9):674-678
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is considered a kind of malignant tumors of the world highest incidence. As it is not sensi-tive to chemotherapy and easy to produce drug resistance, improving effect of anticancer drug becomes a research focus recent years. siRNA, small interfering RNA, can silence complemenary mRNA which is a kind of gene therapy. Target peptides are small molecular peptides which speciifcally bind to tumor surface materials. When used with siRNA, target peptides can in-crease accumulation of siRNA in tumor cells and enhance the silencing effect. As result, drug resistance of lung cancer reduced and the effect of therapy can be improved. hTis method provides new direction and strategy for targeted therapy of lung cancer. hTis article will make a brief overview of target peptides applying in siRNA dilivery for the research of lung cancer treatment.
