Advances in the Molecular Mechanisms and Prognostic Signiifcance of EMT in Non-small Cell Lung Cancer

VernacularTitle:非小细胞肺癌中EMT的发生机制及预后价值的研究进展
Author: CAO QINCHEN ¹ ; ZHAO LUJUN ; WANG PING
Author Information

1. 300060天津，天津医科大学肿瘤医院放疗科，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室
Keywords: Lung neoplasms; Epithelial to mesenchymal transition; Mechanism; Prognosis
From: Chinese Journal of Lung Cancer 2014;(7):569-574
CountryChina
Language:Chinese
Abstract: Epithelial to mesenchymal transition (EMT) has an important role in the development of embryo, as well as that in the metastasis of non-small cell lung cancer (NSCLC). Recent researches have demonstrated that both morpho-logical and phenotypic conversions emerge in cells undergoing EMT. As most of relevant studies were on other cancers, it is es-sential to uncover whether it is the similar mechanisms accounting for EMT in NSCLC. With the progress of the studies, EMT-related basic researches are gradually applied to predicting the prognosis of NSCLC. hTe aim of this article was to discuss the mechanisms related to EMT emerging in NSCLC.