Current Status of Translational Research on Irritable Bowel Syndrome.
10.4166/kjg.2016.68.3.138
- Author:
Yong Hwan KWON
1
;
Hyun Jin KIM
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
- Publication Type:Review
- Keywords:
Irritable bowel syndrome;
Translational medical research;
Biomarkers;
Genetic;
Physiopathology
- MeSH:
Biomarkers;
Gastrointestinal Diseases;
Gastrointestinal Microbiome;
Hypersensitivity;
Inflammation;
Irritable Bowel Syndrome*;
Korea;
Psychology;
Serotonin;
Translational Medical Research*
- From:The Korean Journal of Gastroenterology
2016;68(3):138-142
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. The pathophysiology of IBS is not completely understood. Genetic, immune, environmental, inflammatory, neurological and psychological factors contribute to the risk of this condition. Traditional research explored gastrointestinal motor abnormalities, central neural dysregulation, abnormal psychological features, and visceral hypersensitivity. More recent investigations consider bacterial overgrowth, abnormal serotonin pathways, altered gut flora, immune activation and mucosal inflammation. The purpose of this article is to review recent translational research concerning the pathophysiology, biomarker and genetic factors of IBS and to encourage IBS research in Korea.
