Current Status of Translational Research on Constipation.
10.4166/kjg.2016.68.3.143
- Author:
Hyun Jik LEE
1
;
Kyung Sik PARK
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. seenae99@dsmc.or.kr
- Publication Type:Review
- Keywords:
Constipation;
Translational medical research;
Gastrointestinal motility;
Colon
- MeSH:
Colon;
Constipation*;
Gastrointestinal Motility;
Models, Animal;
Prevalence;
Translational Medical Research*;
Treatment Outcome
- From:The Korean Journal of Gastroenterology
2016;68(3):143-147
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Constipation is one of the most common gastrointestinal disorders with a prevalence up to 16.5% in the general population. It is frequently multifactorial and the pathophysiologic mechanism of constipation is not fully understood. Many preclinical studies of constipation have used animal models. Translational research using these animal models is essential to the investigation of neurogenic and myogenic mechanisms of colon, and to the estimation of the clinical efficacy of new drugs. In this review, we discuss some of the current translational research projects on constipation using animal models.
