Research Progress of Thyroid Transcription Factor-1 as Molecular Marker in Lung Carcinoma
10.3779/j.issn.1009-3419.2014.06.10
- VernacularTitle:肺癌与TTF-1分子标志物研究进展
- Author:
GE XIAOXIAO
1
;
JIANG LIYAN
Author Information
1. 上海交通大学附属胸科医院呼吸科
- Keywords:
Lung neoplasms;
hTyroid nuclear factor-1;
Biological markers
- From:
Chinese Journal of Lung Cancer
2014;(6):491-495
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the leading cause of cancer-related death worldwide. hTe majority of cases, the diagnosis is made at an advanced stage. hTe prognosis is poor with a 5-year survival rate less than 16%and the median overall survival 1 year or so. In recent years, research has focused on the potential role of new biological factors involved in the carcinogenic process. It’s well known that thyroid transcription factor 1 (TTF-1) was a special lineage-survival oncogene in lung cancer ac-cording to recent researches. It has become apparent that TTF-1 expression has biological and clinical functions in the opposite direction that act in tumor progression. Herein, we summarize the role of this transcription factor in the development, diagno-sis, and prognosis of lung cancer in the hope of providing insights into the utility of TTF-1 as a novel biomarker of lung cancer.
