Value of serum lactate dehydrogenase,β2 microglobulin and ferritin combined with modified WHO-based Prognostic Scoring System in predicting poor prognosis of myelodysplastic syndrome
- VernacularTitle:血清乳酸脱氢酶、β2微球蛋白、铁蛋白联合改良WHO预后积分系统预测骨髓增生异常综合征预后不良的价值
- Author:
Jiangwei WAN
1
;
Dongru CHENG
;
Tao WANG
;
Ping GAO
Author Information
- Keywords: lactate dehydrogenase; β2-microglobulin; ferritin; modified WHO-based Prog-nostic Scoring System; myelodysplastic syndrome; prognosis
- From: Journal of Clinical Medicine in Practice 2024;28(5):79-84
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the value of serum lactate dehydrogenase(LDH),β2-mi-croglobulin(β2-MG)and serum ferritin(SF)combined with the modified WHO-based Prognostic Scoring System(WPSS)score in predicting poor prognosis of patients with myelodysplastic syndrome(MDS).Methods A total of 110 patients with MDS were selected as the research objects,and ser-um levels of LDH,β2-MG and SF were detected.The patients were divided into death group and sur-vival group according to their survival status,and the serum levels of LDH,β2-MG and SF as well as the modified WPSS score were compared between the two groups.The risk factors for poor prognosis in MDS patients and the predictive values of serum LDH,β2-MG,SF and modified WPSS score alone and their combination for poor prognosis in MDS patients were analyzed.Results The incidence of poor prognosis in MDS patients was 40.20％(41/102).The serum levels of LDH,β2-MG and SF,the modified WPSS score,and the ratio of adverse karyotype prognosis in the death group were signifi-cantly higher than those in the survival group(P＜0.05).The results of Cox regression model analysis showed that elevated serum levels of LDH,β2-MG and SF,elevated modified WPSS score,and adverse karyotype prognosis were risk factors for poor prognosis in MDS patients(P＜0.05).The results of receiver operating characteristic(ROC)curve analysis showed that the combination of serum LDH,β2-MG,SF levels and modified WPSS score had a sensitivity of 95.12％and an area under the curve(AUC)of 0.918 for predicting poor prognosis in MDS patients,which were significantly high-er than those of each indicator alone(P＜0.05).Conclusion Serum LDH,β2-MG,SF levels and modified WPSS score have certain predictive value for poor prognosis in MDS patients,but the combined prediction value of the four indicators is higher.
