Radiofrequency Ablation for Lung Neoplasms with Isolated Postsurgical Local Recurrences or Metastases of Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2014.06.04
- VernacularTitle:肺癌切除术后肺内孤立性转移复发灶的射频消融治疗
- Author:
LIU BAODONG
1
;
LIU LEI
;
Hu MU
;
QIAN KUN
;
LI YUANBO
;
ZHI XIUYI
Author Information
1. 首都医科大学宣武医院胸外科
- Keywords:
Lung neoplasms;
Metastases;
Recurrence;
Radiofrequency ablation
- From:
Chinese Journal of Lung Cancer
2014;(6):460-464
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Primary lung cancer is one of the most common malignancies worldwide. Surgical resection remains the ifrst choice for the treatment of early stage non-small cell lung cancer (NSCLC). Relapse atfer surgery sharply reduces the patient’s life expectancy. hTis relapse is referred to as isolated postsurgical local recurrences or me-tastases (IPSLROM), which can be treated via local therapy to achieve long-term survival or cure. In recent years, radiofrequen-cy ablation (RFA) has been increasingly used as a non-surgical treatment option for patients with primary and metastatic lung tumors. hTis study aims to evaluate the effcacy of RFA among patients with IPSLROM of NSCLC. Methods A total of 20 patients underwent computerd tomograghy (CT)-guided RFA for lung neoplasm with IPSLROM of NSCLC (with unresect-able disease because of poor lung reserve or multifocality) in our hospital between December 2008 and November 2013. hTese patients comprised 15 males and 5 females with a mean age of 69.2 years (range:45-85). All patients exhibited pathological evidence of neoplastic lesion (14 tumors were adenocarcinoma, and six were squamous cell carcinoma). hTe mean size of the lesions was 3.9 cm (range:2.0 cm to 8.0 cm). Treatment complications, progression-free survival (PFS), and survival param-eters were retrospectively analyzed. Results RFA was well tolerated by all patients with an average time of 34.3 min (range:15 min to 60 min). Intraprocedural complications included eight cases of chest pain (40%). No procedure-related deaths occurred in all of the 20 ablation procedures. hTe median PFS was 25 months in all of the patients who received RFA. hTe median overall survival for the entire group of patients was 27.0 months. No differences were observed in the overall survival between patients with IPSLROM. hTe overall survival rates at 1 and 2 years atfer RFA were 92.9%and 57.0%, respectively. Conclusion RFA is a safe and effective procedure in unresectable lung tumors with IPSLROM of NSCLC.
