High Risk Indication of Postoperative Chemotherapy in Early Stage Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2014.05.09
- VernacularTitle:Ib期肺癌术后辅助化疗高风险因素分析
- Author:
MAO FENG
1
;
PAN YAN
;
LI ZIMING
;
CAI MINGHUI
;
SHEN-TU YANG
Author Information
1. 上海交通大学附属胸科医院/上海市肺部肿瘤临床医学中心胸外科
- Keywords:
Lung neoplasms;
Operation;
Vessel carcinoma embolus;
Prognostic factor
- From:
Chinese Journal of Lung Cancer
2014;(5):411-416
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective More than 35%Ib stage lung cancers have metastasised or recurrenced atfer operation, whose prognosis still remain poor. hTere’re much controversy over the necessity of adjuvant chemotherapy to them. hTis aim of this study is investigated the clinical and pathological characters inlfuencing prognosis of the stage Ib non-small cell lung cancer (NSCLC) and to explore the indication of postoperative chemotherapy. Methods NSCLC patients (281 cases) who underwent lobectomy were examined. Cox proportional-hazards ratios were used to identify independent prognostic fac-tors for survival. Kaplan-Meier survival curves were calculated to estimate survival rates. Results Kaplan-Meier analysis show that, cancerous embolus in the blood vessel or lymphatic vessel, histologic grade and tumor location were remarkerbly associ-ated with mortality risk (P<0.05). hTe poor histologic grade and cancerous embolus in the blood vessel were closely associated with increased mortality risk on multivariate analysis in stage Ib NSCLC. Conclusion hTe low histologic grade and cancerous embolus in the blood vessel or lymphatic vessel are closely correlated with survival in the stage Ib NSCLC and can be an index for the postoperative chemotherapy.
