Advances of the Relationship between Leptin System and Non-small Cell Lung Cancer

VernacularTitle:瘦素系统与非小细胞肺癌关系的研究进展
Author: WEI TENGFEI ¹ ; LU LONGKUN ; SHEN QIAN ; FANG CHAOPING
Author Information

1. 第二军医大学附属长海医院实验诊断科
Keywords: Leptin; Leptin-receptor; Lung neoplasms
From: Chinese Journal of Lung Cancer 2014;(4):347-350
CountryChina
Language:Chinese
Abstract: Leptin system plays an important role in lung inlfammation and tumorigenesis, but the precise function in the tumormicrovironment and the prognosis value of the leptin system in lung cancer have not been fully elucidated. hTis re-view will focus on the relationship between leptin system and non-small cell lung cancer (NSCLC), in which special attentions will be paid on the expression of leption and its receptor (LepR) in peripheral blood and tumor tissues, leptin-related signal transduction pathways, the interaction between leption and regulatory T cells (Treg) and the gene polymorphisms of leptin and leptin receptor, and possibly provide new strategies for diagnosis and treatment of NSCLC.