Long?term outcome of patients with pyriform sinus squamous cell carcinoma treated with planned preoperative (chemo?) radiotherapy plus laryngeal function sparing surgery
10.3760／cma.j.issn.0253?3766.2019.07.010
- VernacularTitle:术前放化疗后保留喉功能手术梨状窝鳞癌患者的预后
- Author:
Hui HUANG
1
;
Zongmin ZHANG
;
Ye ZHANG
;
Xiaolei WANG
;
Shaoyan LIU
;
Zhengang XU
Author Information
1. 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院头颈外科100021
- Keywords:
Pyriform sinus neoplasms;
Preoperative ( chemo?) radiotherapy;
Laryngeal function sparing surgery;
Prognosis
- From:
Chinese Journal of Oncology
2019;41(7):535-539
- CountryChina
- Language:Chinese
-
Abstract:
To analyze the long?term outcome of patients with pyriform sinus squamous cell carcinoma treated with planned preoperative ( chemo?) radiotherapy plus laryngeal function sparing surgery. Methods Patients with stage Ⅲ／Ⅳ pyriform sinus squamous cell carcinoma treated with planned preoperative ( chemo?) radiotherapy plus laryngeal function sparing surgery during 1999 to 2000 were retrospectively analyzed. Data including concurrent chemotherapy or not, postoperative pathological diagnosis, postoperative complications, recurrence and survival were collected. Twenty patients were treated with preoperative radiotherapy while 14 patients with preoperative chemo?radiotherapy. Results Among 31 cases of postoperative pathological diagnosed as pyriform sinus, 12 (38.7%) cases without tumor residue, 7 (22.5%) cases with severe radiation response and 12 ( 38.7%) cases with tumor residue. The 5?year cumulative local recurrence rate, regional recurrence rate and distant metastasis rate was 14.5%, 13.7% and 23.5%, respectively. Five?year cumulative overall survival rate and recurrence?free survival rate were 69.6%and 65.4%, respectively.Nine deaths were attributed to distant metastasis (8 cases) and regional recurrence (1 case). Conclusion Most patients with pyriform sinus squamous cell carcinoma acquire long?term survival after treated with planned preoperative ( chemo?) radiotherapy plus laryngeal function sparing surgery, and distant metastasis is the main cause of death.
