Predictive efficiency of oxidative stress indicators and uterine artery hemodynamic parameters on hypertensive diseases in pregnancy
- VernacularTitle:氧化应激指标联合子宫动脉血流动力学参数对妊娠期高血压疾病的预测效能
- Author:
Xinying BI
1
;
Yong LU
;
Liyang JIA
;
Yanbin ZHANG
;
Wenjing CHU
Author Information
- Keywords: early pregnancy; oxidative stress; hemodynamic parameters; hypertensive disea-ses in pregnancy; preeclampsia
- From: Journal of Clinical Medicine in Practice 2024;28(4):45-49
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the predictive efficiency of combined uterine artery hemo-dynamic parameters and oxidative stress indicators in early pregnancy on hypertensive diseases in pregnancy(HDP).Methods A total of 90 HDP patients(case group)and 30 healthy pregnant women(control group)as research subjects.The case group included 30 patients with pregnancy-in-duced hypertension,30 patients with preeclampsia,and 30 patients with severe preeclampsia,respec-tively,and were divided into pregnancy-induced hypertension group,preeclampsia group,and severe preeclampsia group.Serum levels of reactive oxygen species(ROS),superoxide dismutase(SOD),heme oxygenase-1(HO-1),glutathione peroxidase(GSH-PX),malondialdehyde(MDA),and uterine artery hemodynamic parameters were compared between the two groups in early pregnancy(8 weeks to 13 weeks plus 6 days).The receiver operating characteristic(ROC)curve was used to evaluate the predictive efficiency of relevant indicators for HDP.Results The serum levels of SOD and GSH-PX were lower in the case group than that in the control group,and the serum level of MDA and the uterine artery pulsatility index(PI)were higher in the case group than that in the control group(P＜0.05).The serum levels of SOD and GSH-PX gradually decreased,and the serum levels of MDA and PI gradu-ally increased in the pregnancy-induced hypertension group,the preeclampsia group,and the severe preeclampsia group(P＜0.05).The ROC curve showed that the combination of SOD,GSH-PX,MDA,and PI in early pregnancy had a higher predictive efficiency for HDP,with an area under the curve of 0.824,a sensitivity of 81.1％,and a specificity of 76.7％.Conclusion Patients with HDP have changes in oxidative stress indicators and uterine artery hemodynamic parameters in early preg-nancy,and there are differences among patients with different disease severities.The combined de-tection of SOD,GSH-PX,MDA,and PI in early pregnancy can help predict HDP.
