Advances in Hypoxia Microenvironment and Chemotherapy-resistant of Lung Cancer
10.3779/j.issn.1009-3419.2014.03.14
- VernacularTitle:肺癌低氧微环境与化疗耐药相关性研究进展
- Author:
GUO YANG
1
;
WU MILU
;
ZHAO JUNHUI
;
LI YUYING
Author Information
1. 青海大学
- Keywords:
Hypoxia;
Lung neoplasms;
Chemotherapy;
Drug-resistance
- From:
Chinese Journal of Lung Cancer
2014;(3):265-268
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the malignant tumors with highest incidence recently in our country. Tumor hypoxia phenomenon was ifrst discovered in lung cancer. It plays important roles in tumor cell drug-resistance, apoptosis, inva-sion and metastasis, angiogenesis. Chemotherapy-resistant is one of the core reasons of treatment failure and disease progress, and many works on the study of chemotherapy-resistant have been done. hTis article reviewed the research progress of those mechanisms by which lung cancer hypoxia microenvironment could induce chemotherapy-resistance.
