Nonalcoholic Fatty Liver Disease in Children with Hypopituitarism.
10.5223/kjpgn.2010.13.1.51
- Author:
Jung Min YOON
1
;
Jae Sung KO
;
Jeong Kee SEO
;
Choong Ho SHIN
;
Sei Won YANG
;
Jin Soo MOON
;
Hye Ran YANG
;
Ju Young CHANG
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. kojs@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Child;
Fatty liver;
Hypopituitarism;
Obesity
- MeSH:
Blood Glucose;
Body Mass Index;
Child;
Craniopharyngioma;
Dyslipidemias;
Early Diagnosis;
Fasting;
Fatty Liver;
Fibrosis;
Glucose;
Humans;
Hypertriglyceridemia;
Hypopituitarism;
Liver;
Obesity
- From:Korean Journal of Pediatric Gastroenterology and Nutrition
2010;13(1):51-57
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: It has been reported that children with hypopituitarism have features of metabolic syndrome, including obesity, impaired glucose tolerance, and dyslipidemia. The aim of this study was to investigate the clinical features and liver histology of pediatric non-alcoholic fatty liver disease (NAFLD) associated with hypopituitarism. METHODS: We reviewed the clinical data of 11 children diagnosed with NAFLD among patients with hypopituitarism. RESULTS: The mean age at the time of diagnosis of hypopituitarism was 10.4+/-3.2 years, and the mean age at the time of diagnosis of NAFLD was 13.1+/-2.7 years. A craniopharyngioma was the most common cause of pituitary dysfunction. At the time of diagnosis of NAFLD, 9 patients (82%) had a body mass index greater than the 85th percentile, 5 patients (45%) had elevated fasting blood glucose levels, and 9 patients (82%) had hypertriglyceridemia. The mean height SD score was significantly lower at the time of diagnosis of NAFLD than at the time of diagnosis of hypopituitarism. Of the six patients who were biopsied, one had cirrhosis, two had non-alcoholic steatohepatitis (NASH) with bridging fibrosis, two had NASH with mild portal fibrosis, and one had simple steatosis. CONCLUSION: Children with hypopituitarism are at risk of short stature, obesity, dyslipidemia, and NAFLD. The early diagnosis of NAFLD is important in children with hypopituitarism because advanced fibrosis is common.
