Risk factors of electrocardiogram abnormalities in patients with primary liver cancer and its value in predicting prognosis
- VernacularTitle:原发性肝癌患者心电图异常的危险因素及其预测预后的价值
- Author:
Tianjia DING
1
;
Tao SUN
;
Mingfeng WU
;
Haibing YIN
Author Information
- Keywords: primary liver cancer; electrocardiogram abnormalities; risk factors; prognosis; predictive value; transcatheter arterial chemoembolization
- From: Journal of Clinical Medicine in Practice 2024;28(3):100-104
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the risk factors of electrocardiogram abnormalities in patients with primary liver cancer and its value in predicting prognosis.Methods A total of 120 primary liver cancer patients with transcatheter arterial chemoembolization(TACE)were selected as the research objects,and they were divided into abnormal group(n=32)and non-abnormal group(n=88)ac-cording to incidence of electrocardiogram abnormalities at 7 days after operation.Baseline data and changes in 24-hour QT interval variability(24-hour QTV),standard deviation of the normal R-R in-terval from the beginning of atrial depolarization to ventricular depolarization(SDNN),standard devia-tion of the normal R-R interval for 5 consecutive minutes(SDANN-index),and mean value of the standard deviation of the normal R-R interval for 5 consecutive minutes(SDNN-index)were compared between two groups;a binary Logistic regression model was used to analyze the influencing factors of e-lectrocardiogram abnormalities in patients with primary liver cancer;the receiver operating characteristic(ROC)curve was used to analyze the area under the curve(AUC),sensitivity and specificity of 24 h QTV,SDNN,SDANN-index and SDNN-index in predicting ECG abnormalities in patients with pri-mary liver cancer.Results Of the 120 primary liver cancer patients with TACE treatment,32 ca-ses had electrocardiogram abnormalities,including 13 cases of sinus tachycardia with T-wave chan-ges,2 cases of ST-T changes,4 cases of supraventricular tachycardia,4 cases of QT interval prolon-gation,4 cases of ventricular premature beats,and 5 cases of atrial premature beats.There were no significant differences in gender,age,super-selective hepatic artery catheterization,gelatin sponge embolization,use of chemotherapy drugs,postoperative vomiting,and blood uric acid on the third day after surgery between the abnormal group and the non-abnormal group(P＞0.05);there were significant differences in tumor diameter,liver function classification,dosage of iodized oil,postop-erative body temperature,and blood potassium on the third day after surgery between the two groups(P＜0.05).Logistic regression model showed that tumor diameter ≥10 cm,grade A of liver func-tion classification,iodized oil dose ≥10 mL,postoperative body temperature ≥38 ℃,and decrea-ses of 24 h QTV,SDNN,SDANN-index and SDNN-index were the independent factors affecting e-lectrocardiogram abnormalities in patients with primary liver cancer(P＜0.05).ROC curve analy-sis showed that the values of AUC of 24 h QTV,SDNN,SDANN-index,SDNN-index and compre-hensive electrocardiogram parameters in predicting electrocardiogram abnormalities in patients with primary liver cancer were 0.682,0.651,0.632,0.752 and 0.786 respectively,with statistically significant differences(P＜0.05).Conclusion Tumor diameter,liver function classification,dose of iodide oil and postoperative body temperature can affect electrocardiogram abnormalities in patients with primary liver cancer,and electrocardiogram monitoring before and after TACE treat-ment is conducive to timely detection of electrocardiogram abnormalities.
