Changes in Serum Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 After Video-assisted Thoracoscopic Surgery and Thoracotomic Lobectomy in the Treatment of Patients with Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2014.01.04
- VernacularTitle:非小细胞肺癌胸腔镜与常规开胸术后血清VEGF、MMP-9变化的研究
- Author:
TIAN WENXIN
1
;
TONG HONGFENG
;
SUN YAOGUANG
;
WU QINGJUN
;
MA CHAO
;
JIAO PENG
Author Information
1. 卫生部北京医院胸外科
- Keywords:
Lung neoplasms;
Video-assisted thoracoscopic surgery;
VEGF;
MMP-9
- From:
Chinese Journal of Lung Cancer
2014;(1):24-29
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Vascular endothelial growth factor (VEGF) and matrix metalloprotein-ase-9 (MMP-9) are important factors in angiogenesis. hTese factors function in the angiogenesis of lung cancers. hTe aim of this study is to determine the changes in serum VEGF and MMP-9 atfer patients with NSCLC were subjected to lobectomy. hTe aim of this study is also to compare the differences in the changes observed between video-assisted thoracoscopic surgery (VATS) and traditional open surgery (TOS). Methods A total of 43 consecutive patients with NSCLC were recruited from October 2010 to August 2012. All of these patients underwent lobectomy and systematic mediastinal lymphadenectomy. Blood was drawn from these patients to measure the serum levels of VEGF and MMP-9 in the morning before surgery and on postoperative days1, 2, 3, and 7 (POD1, POD2, POD3, and POD7, respectively). Perioperative variations in serum VEGF and MMP-9 were also observed. Using different surgical options, we divided the patients into two groups:VATS group (25 patients) and TOS group (18 patients). hTe differences in the changes in serum VEGF and MMP-9 were then compared be-tween the two groups. Results Atfer surgery, the serum VEGF and MMP-9 of patients with NSCLC initially increased and subsequently decreased. hTe peak levels were observed on POD2 and POD3, and these levels were signiifcantly higher than the preoperative levels (P=0.031, P=0.020). On POD7, the serum VEGF and MMP-9 remained higher than the preopera-tive levels. In VATS and TOS groups, the serum VEGF and MMP-9 levels also initially increased and subsequently decreased. hTe TOS group showed a more evident variation. However, no signiifcant statistical differences in the changes of VEGF and MMP-9 were found between the two groups (F=2.022, P=0.163;F=1.703, P=0.199). Conclusion Serum VEGF and MMP-9 remarkably increase in TOS group and VATS group. Although the serum level of VEGF an MMP-9 in TOS group were higher than that in VATS group. But no signiifcant difference was observed between VATS and TOS group.
